The activity of the pyruvate dehydrogenase complex is also controlled by phosphorylation. Pyruvate dehydrogenase kinase (PDH kinase) catalyzes the phosphorylation of a specific Ser residue on the E1 subunit of the enzyme, rendering it inactive. Pyruvate dehydrogenase phosphatase (PDH phosphatase) reverses the inhibition by catalyzing the removal of this phosphate group. The PDH kinase is highly regulated and its activity is influenced by various cellular metabolites. Indicate whether the following would activate or inhibit PDH kinase:
Inhibit or activate PDK?
NAD+ activate
NADH inhibit
coenzyme A activate
acetyl-CoA inhibit
ADP inhibit
Did I answer these correctly?

Answers

Answer 1

Answer:

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Explanation:

Pyruvate dehydrogenase kinase, PDK is an enzyme which acts to inhibit the activity of the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. It mechanism of action is by catalyzing the phosphorylation of a specific Ser residue on the E1 subunit of the pyruvate dehydrogenase complex, rendering it inactive. By inhibiting the activity of the pyruvate dehydrogenase complex, PDK will decrease the oxidation of pyruvate to acpcetyl-coA and CO₂ in the mitochondria and increase the conversion of pyruvate to lactate in the cytosol.

Since pyruvate dehydrogenase complex is activated by either an increase in the concentration of one or more of ADP, NAD+ or CoA-SH, its inhibitor pyruvate dehydrogenase kinase is inhibited by ADP, NAD+, CoA-SH and pyruvate. However, PDK is activated by increase in the concentration of ATP, NADH and acetyl-CoA.

Therefore, the correct answers are:

Increase in [NAD+] inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Increase in [NADH] activates Pyruvate dehydrogenase kinase (PDH kinase)

Coenzyme A inhibits Pyruvate dehydrogenase kinase (PDH kinase)

Acetyl-co A activates Pyruvate dehydrogenase kinase (PDH kinase)

ADP inhibits Pyruvate dehydrogenase kinase (PDH kinase)


Related Questions

PLZ HELLLP TONS OF POINTS (this is on a FINAL)
two students are comparing scientific experiments to investigations. They came up with the following ideas.

Student A: Testing plant growth in different types of soils
Student B: Comparing the water level in a lake during different times of the year

Which student gave an example of a scientific experiment?

Student A because it requires experimental and control groups
Student B because it requires a hypothesis
Student A because it is preferably done in natural settings
Student B because it is preferably done across a long period of time

Answers

Answer:A

Explanation:

Every cell in your body was produced through successive rounds of mitosis, starting from the zygote.

a. True
b. False

Answers

Answer:

I think that the correct answer is True

A scientist helps a colleague do a better experiment by:
O A. refusing to consider an alternative interpretation of results.
B. suggesting that unrepeatable results are still reliable.
C. making up observations that are hard to obtain directly
D. sharing the cost of an expensive tool or instrument.

Answers

Answer:

I think C

Explanation:

it is good reason

The scientist that helped to colleague for doing a good experiment when the expensive tool or instrument should be shared.  

What is an experiment?

An experiment refer to the procedure where it should be carried out for supporting or refuting a hypothesis. It provides the cause and effect relationship by represent the result that arise at the time when the specific factor should be changed.

And,  when the expensive tool cost should be shared so the more good experiment should be conducted.

hence, the option d is correct and the rest options should be incorrect.

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PLS HELP ASAP!!!! 60 points!

in complete sentences compare in depth each of the following:

Compare their functions
Compare their structures
Compare how they look when they are stained
Compare their counts

Answers

Compare everything you have then dived by 0.7826 you’ll get the answer

What is true for an energy resource with a low net energy?

Answers

Answer:

An energy resource with a low or negative net energy can have a hard time competing in the marketplace with other energy alternatives that have medium to high net energy yields unless it receives financial support from the government (taxpayers) or other outside sources.

Explanation:

- Eijiro <3

Which of the following does the frog represent? A. Primary producer B. Primary consumer C. Secondary consumer D. Decomposer

Answers

Answer:

Primary Consumer

Explanation:

Because it eat directly from the plants, which are primary producers

why is night blindness regarded as a non infectious disease​

Answers

Answer:

Explanation:

stay away from the dark frfr sh1 creepy dog

All of the following are actions one may participate in if they are seeking group therapy except __________.
A. describing problems
B. sharing experiences
C. providing emotional support
D. setting goals for the group

Answers

Answer:

D

Explanation:

d is the answer, hope this helps

Which of the following is a true statement? Physical property change is always better than chemical property change.
o Physical and chemical propery change can happen at the same time.
Chemical property change is better than physical property change.​

Answers

Answer:

the second one

Explanation:

Sometimes it can be tricky to know whether or not a chemical reaction has occurred. For example, when you melt ice into water, you can write the process in terms of a chemical reaction. However, the chemical formula on both sides of the reaction is the same. Since the chemical identity of the matter in question is unchanged, this process represents a physical change.

Thus melting point is a physical property. On the other hand, flammability is a chemical property of matter because the only way to know how readily a substance ignites is to burn it. In the chemical reaction for combustion, the reactants and products are different.

none are better, depending on for what

A scientist isolates a disease-causing particle. Which of the following properties would indicate that the particle is a virus and not a bacterium?

Answers

A virus is usually spread through the air and such whereas bacteria is spread through contact

Which of the following mutations could lead to constitutive expression of the genes of the lac operon? View Available Hint(s) Which of the following mutations could lead to constitutive expression of the genes of the lac operon? A mutation in the lac-Z gene A mutation in the lac-Y gene A mutation in the operator sequence A super repressor mutation Submit Part B Which of the following best describes the biological role of the lac operon? View Available Hint(s) Which of the following best describes the biological role of the lac operon? It ensures that bacterial cells produce lactose only when no other food sources are available. It ensures that a cell dedicates resources to the production of enzymes involved in lactose metabolism only when lactose is available in the environment. It ensures that a cell produces enzymes involved in lactose metabolism in a constitutive manner. It prevents other sugars from being metabolized until all available lactose has been used. Submit Part C The placement of the operator sequence between the promotor and the structural genes is critical to the proper function of the lac operon. View Available Hint(s) The placement of the operator sequence between the promotor and the structural genes is critical to the proper function of the lac operon. True False

Answers

Options for part A are as follows:

A) A mutation in the operator sequence

B) A mutation in the lac-Z gene

C) A mutation in the lac-Y gene

D) A super repressor mutation

Answer:

The correct answer:

Part a - A mutation in the operator sequence

Part b - It ensures that a cell dedicates resources to the production of enzymes involved in lactose metabolism only when lactose is available in the environment

Part C. true.

Explanation:

part a:

If there is a mutation in the operator sequence leads to prevent binding of the repressor which leads to allowing constitutive expression of the genes various conditions.

part b:

The biological role of the lac operon makes sure that the cell dedicates resources to the production of enzymes involved in lactose metabolism only when lactose is available in the environment

Part c:

RNA polymerase cannot transcribe the structural genes due to the repressor binds to the lac operator, therefore, the proper function of the lac operon is possible when the placement of the operator sequence between the promotor and the structural genes.

Discribe blood cells and give their proper function. what makes difference on red blood cells to other types of cells of human?​

Answers

Answer:

white blood cells help in the body in this action is to fight against diseases in the body while red blood cells help transport oxygen and nutrients in body

Blood cells and supply their proper feature: The red blood cell's important feature is to carry oxygen from the lungs and supply it during our body. red blood cells additionally transport waste including carbon dioxide returned to our lungs to be exhaled. Red blood cells can convey oxygen because of a protein known as hemoglobin.

How are human red blood cells exclusive from all different human cells?

Red blood cells are microscopic and feature the shape of a flat disk or doughnut, that is round with an indentation within the middle, however it is not hollow. red blood cells do not have a nucleus like white blood cells, allowing them to change shape and flow for the duration of your body less difficult.

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2. Which part of a eukaryotic cell contains the instructions on how to recombine the molecules in nutrients into new molecules that the cell can use?

A. DNA in the nucleus
B. Chlorophyll in chloroplasts
C. Water in vacuoles
D. Digestive chemicals in lysosomes

Answers

A. DNA in the nucleus.
Our nucleus in each cell encodes messages for other organelles to acquire. The organelles use these messages to sustain everyday activities.
Chloroplasts function to convert solar energy into energy the cell can use in a plant cell.
Vacuoles store water, molecules, waste and other substances.

Water flow improves in the aftermath of a forest fire because
rain always puts out fires.
no living organisms survive fires, decreasing demand.
they clear the land, allowing more water to flow over it.
much of the water in a local watershed will be used to fight the fire.

Answers

A major impact of combustion on water quality is the potential for increased precipitation. Runoff can carry suspended soil particles, dissolved inorganic nutrients, and other materials into nearby rivers and lakes, degrading water quality and damaging fish habitat.

Park Williams, an associate professor of geography at UCLA and lead author of the study, said wildfires burn vegetation that would otherwise draw water from the ground and block precipitation before it reaches the ground. said to improve the flow.

Wildfires increase the vulnerability of watersheds to flooding and erosion, causing short-term and long-term damage to water supplies. may have an impact. The increased cost of treatment, the need for alternative medicine, and reduced storage capacity. Fire as a destructive force can rapidly consume large amounts of biomass and cause adverse effects such as soil erosion, post-fire water runoff, and air pollution.

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Answer: The correct answer is they clear the land, allowing more water to flow over it.

Explanation:  Confirmed correct.

Forest fires clear the underbrush and branches from the forest floor, improving the water flow and saturation.

What is the BEST description of the beginning of secondary succession?
(a)Soil is already present.
(b)It begins on rock formations.
(c)Plants are already present.
(d)Pioneer species appear.

Answers

Answer:

C,,, Plants are already present.

Explanation:

Answer:

Plants are already present.

Explanation:

What are two types of animal waste?

Answers

Answer:

Throughout the following segment, the summary of the given question is summarized.

Explanation:

Animal wastes were most typically thought of as excretory products somewhat from living organisms.

The two types of waste are:

Biodegradable:

The certain commodity that could be quickly decomposed by moisture or water, oxygen, sunlight, or microbes has been considered biodegradable waste.

Non-biodegradable:

Material has always been characterized as such a substance that can't be disassociated via living phenomena as well as being a pollutant.

what type of membrane is the visking tubing​

Answers

Answer: semi-permeable

Explanation: Dialysis tubing, also known as Visking tubing, is an artificial semi-permeable membrane tubing used in separation techniques, that facilitates the flow of tiny molecules in solution based on differential diffusion.

Answer:   semi-permeable

what signals the end of the cell cycle

Answers

G2 checkpoint

If the checkpoint mechanisms detect problems with the DNA, the cell cycle is halted and the cell attempts to either complete DNA replication or repair the damaged DNA. If the DNA has been correctly replicated, cyclin dependent kinases (CDKs) signal the beginning of mitotic cell division.

PLEASE HELP!!!
what protein is part of the basal lamina outside blood vessels, and activates platelets when they stick to it?
-hemoglobin
-collagen
-fibrinogen
-tissue factor​

Answers

Tissue factor, I think.

Study the energy pyramid.

In this pyramid, what level is the frog?

Answers

Answer:

Tertiary consumers i think

Which organism obtains energy without directly depending on another organism

Answers

The organism that obtains energy without directly depending on another organism is a PLANT.

PLANTS are organisms which are capable of manufacturing their own food  through the process of photosynthesis.

Photosynthesis is defined as the process by which plants use low energy containing inorganic compounds (example carbondioxide and water) in the presence of sunlight, as energy, to produce high energy organic compounds such as sugar. These sugar are used as source of energy in the plant cells.

While animals are the organisms that directly depend on plants( another organism)

Therefore, the organism that obtains energy without directly depending on another organism is a PLANT.

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What is the term used for genetic mutations that may result in neutral or even negative outcomes?(1 point)

A) genetic drift

B) natural selection

C) artificial selection

D) genetic modification

Answers

Answer:

Genetic Drift

Explanation:

Evolutionary change can and does occur without natural selection. This usually occurs as a result of genetic drift: genetic mutations that may result in neutral or even negative outcomes.

The term 'GENETIC DRIFT' is used for genetic mutations that may result in neutral or even negative outcomes (Option A).

Genetic drift refers to random fluctuations in the frequency of a given gene variant (i.e. an allele) and different genes in the individuals that form a population.

Genetic drift may occur on neutral or negative alleles carried out by the individuals of a population.

These random fluctuations cause changes in the allele frequencies, which are fixed when they reach a frequency equal to one (1).

In conclusion, the term 'GENETIC DRIFT' is used for genetic mutations that may result in neutral or even negative outcomes (Option A).

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Which of the following is undesirable when developing organic compost?
a)treated sawdust
b)decomposition
c)nematodes
d)kitchen detritus

Answers

it is either b or d. good luck

Answer:

C.

Explanation:

nematodes are roundworms and are undesirable

Please help me !
What is an example of two species working agains each other in an ecosystem??
Thank you!

Answers

Answer:

just think of the food chain

Explanation:

example the lion and the antelope

Describe how the EMG signal (a voltage) arises from muscle activity

Answers

Answer: The EMG signal is a biomedical signal that measures electrical currents generated in muscles during its contraction representing neuromuscular activities. The nervous system always controls the muscle activity (contraction/relaxation). ... EMG signal acquires noise while traveling through different tissues. EMG signals are recorded by placing electrodes close to the muscle groups. When the muscle is activated, the length of the muscle decreases and the muscle, skin and electrodes move with respect to one another. At that time, the electrodes will show some movement artifacts

Explanation:

EMG signals are recorded by positioning electrodes close to the muscle groups. It is the arrangement that helps in the monitoring of EMG signals from muscle activity.

What do you mean by EMG signals?

EMG signals may be defined as a biomedical signal that estimates electrical currents provoked in muscles during their contraction illustrating neuromuscular activities.

When the muscle is stimulated for any mechanism, the length of the muscle declines, which leads to the muscle, skin, and electrodes moving with regard to one another.

The EMG signals always arise from the electrical activity of the muscle fibers which are stimulated during the time of contraction.

Therefore, EMG signals are recorded by positioning electrodes close to the muscle groups. It is the arrangement that helps in the monitoring of EMG signals from muscle activity.

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In humans, nearly 80% of proteins are acetylated on their N-terminal residue, a modification known to be recognized by a specific E3 enzyme, which directs the ubiquitylation of the protein for rapid degradation. Does this mean that all of these proteins would be actively degraded at the same time

Answers

Answer:

Yes

Explanation:

Yes this means that all of these proteins will be actively degraded and this is due to the high turnover rate which will ensure that their activity will be under tight control.

The acetylation of the N-terminal of the protein, with the Ubiquitylation of the protein by an E3 enzyme, helps in the maintenance of the homeostasis of protein activity.

help pls for brainliest

Answers

Answer:

There are two people affected

Explanation:

The black shapes are affected people, the white ones are unaffected

If all of your cells have the same complete set of DNA why do different cells in different proteins

Answers

Why do we have different cells in our bodies if every cell has the same DNA?

The genome of a cell contains in its DNA sequence the information to make many thousands of different protein and RNA molecules. A cell typically expresses only a fraction of its genes, and the different types of cells in multicellular organisms arise because different sets of genes are expressed.

which two places is aggregate generally found?

floodplains and alluvial fans
alluvial fans and mines
mines and beneath the topsoil
beneath the topsoil and above the topsoil

Answers

Answer: Floodplains and Alluvial Fans

Explanation: Took the quiz and got it right. Hope this helps!

Answer:person above is right

Explanation:

answer A

How would adding finer particles to the sand affect porosity?

Answers

Explanation:

Porosity depends on the size, shape, and mixture of grains and particles that compose soil and rock. For instance, small particles such as clays can compact more closely together, reducing the amount of porosity. However, larger particles such as sand and gravel will have more spaces available between them.

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